Synthra C-11 Choline
Production of C-11 Choline
A completely automated synthesis system for routine production of C-11 Choline by cartridge separation and purification. Using in-target produced Carbon dioxide, utilizing gas phase [11C]-CH3I reactions, high specific activity preparations of [11C]-CH3I are produced ranging from 15 Ci/µmol to 50 Ci/µmol when high purity target gas is used for [11C]-CO2 production.
On column methylation with CH3I is applied for the generation of C-11 Choline. Further cartridge purification and formulation yields in a fast and reliable production without the use of a Radio-HPLC.
Examples for [11C] compounds
|Choline||Choline kinase||Brain tumors, prostate, lung and esophageal cancer|
Yields and specific activity of labelled C-11 tracers are dependent on use of proper technique and appropriate reagents.
|Yields||>50 % for [11C]-CH3I in less than 8 min|
|Maximum [11C]-CO2 starting activity||370 GBq|
|Synthesis time for C-11-Choline||20 min|
|Yield for C-11 Choline [RCY]||30%|
|Radiochemical Purity for C-11-Choline||>98%|
|Time for sequential synthesis||<10 minutes|
|Number of consecutive [11C]-CH3I synthesis||15|
|Dimensions||55 x 48 x 50 cm (w x d x h)|
|Weight||Approx. 40 Kg|
|Hot Cell (minimum size)||65 x 50 x 50 cm (w x d x h)|